Einat Liebenthal, D.Sc.
PI, Speech Imaging Lab
Medical College of Wisconsin
Department of Neurology
8701 Watertown Plank Rd
Milwaukee, WI 53226
Research in the Speech Imaging Lab focuses on the neurophysiology of speech perception in healthy adults and children, and in developmental dyslexia. The research has implications for theoretical models of neural organization of language and language development, for understanding and rehabilitation of neurological conditions and developmental learning disabilities in which speech perception may be compromised, and for presurgical mapping in patients with epilepsy or brain tumor.
Research methods include the development of sophisticated stimulus material and experimental paradigms, psychophysical testing and training, neuropsychological evaluation, and multimodal neuroimaging, including functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and simultaneous fMRI/EEG.
A technological research aim is to improve acquisition and analysis methods for simultaneous fMRI/EEG to study speech perception with both high-spatial and high-temporal resolution, and for non-invasive characterization of normative neurovascular coupling.
Speech Imaging Lab: selected current projects
- Conant LL, Liebenthal E, Desai A, Binder JR. Neural substrates of Phonemic Perception in Children (2007). J. Cog. Neurosci. Suppl., pp. 255.
- Sabri M, Liebenthal E, Desai A, Mangalathu J, (2010). Neural correlates of interaural integration in duplex speech perception. Society for Neuroscience, 170.12/FF16.
- Conant LL, Liebenthal E, Desai A, Binder JR (2011). Phonemic perception in children with developmental dyslexia: An fMRI study. Society for Neuroscience, 775.27/U2.
- Liebenthal E, Desai R, Humphries C, Sabri M. (2011). The functional organization of the left STS: a large scale meta-analysis of PET and fMRI studies. Human Brain Mapping, 794 WT and oral session.
- Mangalathu J, Liebenthal E, Beardsley S (2011). Experimental and theoretical evaluation of joint-independent component analysis for the integration of multi-channel ERP and fMRI data. Society for Neuroscience, Nanosymposium 647: Computational Modeling and Simulation V.
- Mangalathu J, Beardsley S, Liebenthal E (2012). Within-subject joint independent component analysis of simultaneous fMRI / ERP in an auditory oddball paradigm. Neuroimage, In Press.
- Sabri M, Humphries C, Binder JR, Liebenthal E (2011). Neural events leading to and associated with detection of sounds under high processing load. Human Brain Mapping, doi: 10.1002/hbm.21457. [Epub ahead of print].
- Liebenthal E, Desai R, Ellingson ML, Ramachandran B, Desai A, Binder JR (2010). Specialization Along the Left Superior Temporal Sulcus for Phonemic and Non-phonemic Categorization. Cerebral Cortex, 20(12):2958-2970.
- Humphries C, Liebenthal E, Binder JR (2010). Tonotopic organization of human auditory cortex Neuroimage, 50:1202-1211.
- Desai R, Liebenthal E, Waldron E, Binder JR. (2008). Left Posterior Temporal Lobe Regions are sensitive to auditory Categorization. J. Cog. Neurosci. 20(7):1174-88.
- Sabri M, Binder JR, Desai R, Medler DA, Leitl MD, Liebenthal E (2008). Attentional and Linguistic Interactions in Speech Perception. Neuroimage, 39(3):1444-56.
- Humphries C, Binder JR, Medler DA, Liebenthal E (2007) Time course of semantic processes during sentence comprehension: an fMRI study. Neuroimage, 36(3):924-32.
- Binder JR, Medler DA, Westbury CF, Liebenthal E, Buchanan L (2006). Tuning of the left fusiform gyrus to sublexical orthographic structure. Neuroimage, 33(2):739-748.
- Sabri M, Liebenthal E, Waldron EJ, Medler, DA, Binder JR (2006). Attentional modulation in the detection of irrelevant deviance: A Simultaneous ERP/fMRI Study. J. Cog. Neurosci., 18(5):689-700.
- Humphries C, Binder JR, Medler DA, Liebenthal E (2006). Syntactic and semantic modulation of neural activity during auditory sentence comprehension. J. Cog. Neurosci., 18(4):1-15.
- Binder JR, Medler DA, Desai R, Conant LL, Liebenthal E (2005). Some Neurophysiological constraints on Models of Word Naming. Neuroimage, 27(3):677-693.
- Desai R, Liebenthal E, Possing ET, Waldron E, Binder JR (2005). Volumetric vs. Surface-based Alignment for Localization of Auditory Cortex Activation. Neuroimage, 26(4):1019-1929.
- Liebenthal E, Binder JR, Spitzer SM, Possing ET, Medler DA (2005). Neural substrates of phonemic perception. Cerebral Cortex, 15(10):1621-1631.
- Binder JR, Liebenthal E, Possing ET, Medler DA, Ward, BD. (2004) Neural correlates of sensory and decision processes in auditory object identification. Nature Neurosci., 7 (3):295-301.
- Ellingson ML, Liebenthal E, Spanaki MV, Prieto TE, Binder JR, Ropella KM (2004). Reduction of Ballistocardiogram artifact in the simultaneous acquisition of auditory event-related potentials and functional resonance images. Neuroimage, 22 (4):1534-1542.
- Liebenthal E, Ellingson ML, Spanaki MV, Prieto TE, Ropella KM, Binder JR (2003) Simultaneous ERP and FMRI of the auditory cortex in a passive oddball paradigm. Neuroimage, 19 (4):1395-1404.
- Liebenthal E, Binder JR, Piorkowski RL, Remez RE. (2003) Short-Term Reorganization of Auditory Cortex Induced by Phonetic Expectation. J. Cog. Neurosci. 15 (4):549-558.
- Liebenthal E, Pratt H. (1999) Human auditory cortex electrophysiological correlates of the Precedence effect: Binaural echo lateralization suppression. J. Acoust. Soc. Am., 106:291-303.
- Liebenthal E, Pratt H. (1997) Evidence for primary auditory cortex involvement in the echo suppression precedence effect: a 3CLT study. J Basic Clin. Physiol. Pharmacol. 8 (3):185-201.
- Liebenthal E, Uhlmann O, Camhi J M. (1994) Critical parameters of the spike trains in a cell assembly: coding of turn direction by the giant interneurons of the cockroach. J Comp. Physiol. A 174 : 281-296.
- Liebenthal E (2011). Introduction to Brain Imaging. In: Biomechanics of the Brain. Ed: Karol Miller. Biological and Medical Physics, Biomedical Engineering, Springer Science+Business Media, LLC, p. 41-68, DOI 10.1007/978-1-4419-9997-9.
- Bradley Goodyear, Liebenthal E, Victoria Mosher. Active and passive fMRI for presurgical mapping of motor and language cortex. In: Advanced topics in brain neuroimaging: Methods and applications. Eds: Dorina Papageorgiou, George Christopolous. InTech, In Press.
last updated: February 2012